The Holiday Inn Express Chillicothe Hotel is located off the Main St. Exit, from Rt 35, 50 and 23 near Historical downtown & shopping. Local companies include: Mead Paper, CSX Railroad, North Folk Southern Railway, Kenworth Trucking and the Adena Regional Medical Center. Hotel features include complimentary continental breakfast and free local phone calls. Enjoy a unique breakfast experience at our new Express Start Breakfast Bar served every morning featuring a selection of fruits, juices, cereals, breads/pastries, and even hardboiled eggs. We have also created the world's best tasting cinnamon roll. Visit Chillicothe, OH and stay smart at the Holiday Inn Express Hotel.